Our group at the MND & Neurotrophic Research Laboratory, Flinders Health & Medical Research Institute, Flinders University, Australia has been leading the world, in describing urinary biomarkers for motor neuron disease. We hypothesise urinary biomarkers, which are easily accessible for sample collection purposes, could be used to determine and predict disease prognosis and facilitate improved clinical trial design to establish efficacy of new therapeutics in motor neuron disease.  Thus far, we have characterised 2 urinary biomarkers, one of which (p75ECD) has being proposed as a pharmacodynamic marker.

Contribution:

• As an external partner: we will be focus on measuring urinary biomarkers in the preModi samples